This post shares information on our work in the area of matrix effects. Matrix effects in LCMS can affect sensitivity, precision and accuracy. We have developed a simple way to monitor phospholipids and lysophospholipids which yield matrix effects. This approach is easily used in developing MRM LC-MS-MS analyses.
I have attached several links on the internet including:
ASMS Poster Sessions:
Prepress of Journal Article:
A published copy of the article can be found at J. L. Little, M. F. Wempe, C. M. Buchanan, Journal of Chromatography B, 833 (2006) 219-230.
A "Little" Mass Spec and Sailing 
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