Posted by: tvasailor | May 1, 2011

Identification of Artifacts in Diazomethane and Trimethysilyldiazomethane Derivatization Reactions

Return to Home Page


SAFETY NOTE:  Diazomethane and Trimethylsilyldiazomethane are dangerous chemicals.  Extreme caution should be taken in handling and using these compounds.  Here are links to information from Wikipedia:




This post summarizes artifacts (reaction by-products) noted in our laboratory from these derivatization reagents.  It was a handout for a poster session at an ASMS conference.  The work was never formally published.  Diazomethane and Trimethylsilyldiazomethane reactions are often used to form methyl ester derivatives to increase the volatility and stability of organic compounds for gas chromatography mass spectrometry. Normally the reactions give the desired derivatives. However, sometimes artifacts (by-products) are noted.



The handout linked below lists all the types of artifacts noted in our laboratory in the last 15 years and ones we have found in the literature.


Return to Home Page

Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s


%d bloggers like this: