Posted by: tvasailor | May 1, 2011

Identification of Artifacts in Diazomethane and Trimethysilyldiazomethane Derivatization Reactions

Return to Home Page

**********************************************************************

SAFETY NOTE:  Diazomethane and Trimethylsilyldiazomethane are dangerous chemicals.  Extreme caution should be taken in handling and using these compounds.  Here are links to information from Wikipedia:

Diazomethane_wikipedia

Trimethylsilyldiazomethane_wikipedia

*********************************************************************

This post summarizes artifacts (reaction by-products) noted in our laboratory from these derivatization reagents.  It was a handout for a poster session at an ASMS conference.  The work was never formally published.  Diazomethane and Trimethylsilyldiazomethane reactions are often used to form methyl ester derivatives to increase the volatility and stability of organic compounds for gas chromatography mass spectrometry. Normally the reactions give the desired derivatives. However, sometimes artifacts (by-products) are noted.

The handout linked below lists all the types of artifacts noted in our laboratory in the last 15 years and ones we have found in the literature.

diazomethane_trimethylsilyldiazomethane_artifacts

Return to Home Page

About these ads

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s

Categories

Follow

Get every new post delivered to your Inbox.

%d bloggers like this: